Keywords
How to Cite
Abstract
Peripheral nerve injury is a serious and disabling disease prevalent in the world. It caused by trauma is often accompanied with soft tissue injuries, fractures, infections, etc., and can cause permanent damage. The treatment methods of peripheral nerve injury mainly include traditional microsurgical repair, neurotrophic drug treatment, as well as cuttingedge nerve conduit treatment, nerve stimulation, cell therapy, etc. However, more than 30% of patients with peripheral nerve injury still have poor recovery, including partial loss or complete loss of motor and/or sensory function, muscle atrophy，chronic pain and severe disability, among can lead to permanent disease. Phenolic compounds are secondary metabolites which is the most abundant in plants, consisting of an aromatic ring and one or more hydroxyl substituents, the main groups including flavonoids, phenolic acids, tannins, stilbene and lignans. A lot of studies have shown that natural phenolic compounds have various properties, such as antioxidant, anti-infective, anticancer, anti-inflammatory, etc., and have broad applications in the prevention of heart disease, cancer, diabetes, oxidative stress-related diseases, and neuroprotection prospect. This review discusses the potential applications and molecular mechanisms of natural phenolic compounds its polymer derivatives in the treatment of peripheral nerve injury.
References
Adiguzel, E., et al., Peripheral nerve injuries: Long term follow-up results of rehabilitation. J Back Musculoskelet Rehabil, 2016. 29(2): p. 367-371.
Nagappan, P.G., H. Chen, and D.Y. Wang, Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury. Mil Med Res, 2020. 7(1): p. 30.
Grinsell, D. and C.P. Keating, Peripheral nerve reconstruction after injury: a review of clinical and experimental therapies. Biomed Res Int, 2014. 2014: p. 698256.
Alu'datt, M.H., et al., A review of phenolic compounds in oil-bearing plants: Distribution, identification and occurrence of phenolic compounds. Food Chem, 2017. 218: p. 99-106.
Lin, D., et al., An Overview of Plant Phenolic Compounds and Their Importance in Human Nutrition and Management of Type 2 Diabetes. Molecules, 2016. 21(10).
Soto-Vaca, A., et al., Evolution of phenolic compounds from color and flavor problems to health benefits. J Agric Food Chem, 2012. 60(27): p. 6658-77.
Middleton, E., Jr., Effect of plant flavonoids on immune and inflammatory cell function. Adv Exp Med Biol, 1998. 439: p. 175-82.
Kumar, S. and A.K. Pandey, Chemistry and biological activities of flavonoids: an overview. ScientificWorldJournal, 2013. 2013: p. 162750.
de Araújo, K.M., et al., Identification of Phenolic Compounds and Evaluation of Antioxidant and Antimicrobial Properties of Euphorbia Tirucalli L. Antioxidants (Basel), 2014. 3(1): p. 159-75.
Szczurek, A., Perspectives on Tannins. Biomolecules, 2021. 11(3).
Alqahtani, A., et al., Seasonal Variation of Triterpenes and Phenolic Compounds in Australian Centella asiatica (L.) Urb. Phytochem Anal, 2015. 26(6): p. 436-43.
Pietrofesa, R.A., et al., Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced perito-neal inflammation in mice. Carcinogenesis, 2016. 37(2): p. 177-87.
Meng, T., et al., Anti-Inflammatory Action and Mechanisms of Resveratrol. Molecules, 2021. 26(1).
Xu, C.C., et al., Advances in extraction and analysis of phenolic compounds from plant materials. Chin J Nat Med, 2017. 15(10): p. 721-731.
Khoddami, A., M.A. Wilkes, and T.H. Roberts, Techniques for analysis of plant phenolic compounds. Molecules, 2013. 18(2): p. 2328-75.
Campbell, W.W., Evaluation and management of peripheral nerve injury. Clin Neurophysiol, 2008. 119(9): p. 1951-65.
Conforti, L., J. Gilley, and M.P. Coleman, Wallerian degeneration: an emerging axon death pathway linking injury and disease. Nat Rev Neurosci, 2014. 15(6): p. 394-409.
Hussain, G., et al., Current Status of Therapeutic Approaches against Peripheral Nerve Injuries: A Detailed Story from Injury to Recovery. Int J Biol Sci, 2020. 16(1): p. 116-134.
Tomlinson, J.E., et al., Temporal changes in macrophage phenotype after peripheral nerve injury. J Neuroinflammation, 2018. 15(1): p. 185.
Jessen, K.R. and R. Mirsky, The repair Schwann cell and its function in regenerating nerves. J Physiol, 2016. 594(13): p. 3521-31.
Pfister, B.J., et al., Biomedical engineering strategies for peripheral nerve repair: surgical applications, state of the art, and future challenges. Crit Rev Biomed Eng, 2011. 39(2): p. 81-124.
Wang, M.L., et al., Peripheral nerve injury, scarring, and recovery. Connect Tissue Res, 2019. 60(1): p. 3-9.
Gordon, T., Peripheral Nerve Regeneration and Muscle Reinnervation. Int J Mol Sci, 2020. 21(22).
Kubiak, C.A., et al., State-of-the-Art Techniques in Treating Peripheral Nerve Injury. Plast Reconstr Surg, 2018. 141(3): p. 702-710.
Cohen, S.P. and J. Mao, Neuropathic pain: mechanisms and their clinical implications. Bmj, 2014. 348: p. f7656.
Held, M., et al., Sensory profiles and immune-related expression patterns of patients with and without neuropathic pain after peripheral nerve lesion. Pain, 2019. 160(10): p. 2316-2327.
Mustonen, L., et al., What makes surgical nerve injury painful? A 4-year to 9-year follow-up of patients with inter-costobrachial nerve resection in women treated for breast cancer. Pain, 2019. 160(1): p. 246-256.
Finnerup, N.B., R. Kuner, and T.S. Jensen, Neuropathic Pain: From Mechanisms to Treatment. Physiol Rev, 2021. 101(1): p. 259-301.
Rawal, N., Current issues in postoperative pain management. Eur J Anaesthesiol, 2016. 33(3): p. 160-71.
Sun, J., et al., Role of curcumin in the management of pathological pain. Phytomedicine, 2018. 48: p. 129-140.
Di, Y.X., et al., Curcumin attenuates mechanical and thermal hyperalgesia in chronic constrictive injury model of neuropathic pain. Pain Ther, 2014. 3(1): p. 59-69.
Zhang, X., et al., Curcumin Alleviates Oxaliplatin-Induced Peripheral Neuropathic Pain through Inhibiting Oxidative Stress-Mediated Activation of NF-κB and Mitigating Inflammation. Biol Pharm Bull, 2020. 43(2): p. 348-355.
Hu, X., et al., PLGA-Curcumin Attenuates Opioid-Induced Hyperalgesia and Inhibits Spinal CaMKIIα. PLoS One, 2016. 11(1): p. e0146393.
Xie, W., et al., Administration of Curcumin Alleviates Neuropathic Pain in a Rat Model of Brachial Plexus Avulsion. Phar-macology, 2019. 103(5-6): p. 324-332.
Ghorbani, A. and M. Esmaeilizadeh, Pharmacological properties of Salvia officinalis and its components. J Tradit Comple-ment Med, 2017. 7(4): p. 433-440.
Rahbardar, M.G., et al., Rosmarinic acid attenuates development and existing pain in a rat model of neuropathic pain: An evidence of anti-oxidative and anti-inflammatory effects. Phytomedicine, 2018. 40: p. 59-67.
da Silva, S.B., et al., Natural extracts into chitosan nanocarriers for rosmarinic acid drug delivery. Pharm Biol, 2015. 53(5): p. 642-52.
El Gabbas, Z., et al., Salvia officinalis, Rosmarinic and Caffeic Acids Attenuate Neuropathic Pain and Improve Function Recovery after Sciatic Nerve Chronic Constriction in Mice. Evid Based Complement Alternat Med, 2019. 2019: p. 1702378.
Cheng, H., et al., Caffeic acid phenethyl ester attenuates neuropathic pain by suppressing the p38/NF-κB signal pathway in microglia. J Pain Res, 2018. 11: p. 2709-2719.
Ye, G., et al., Quercetin Alleviates Neuropathic Pain in the Rat CCI Model by Mediating AMPK/MAPK Pathway. J Pain Res, 2021. 14: p. 1289-1301.
Yang, R., et al., Quercetin relieved diabetic neuropathic pain by inhibiting upregulated P2X(4) receptor in dorsal root ganglia. J Cell Physiol, 2019. 234(3): p. 2756-2764.
Shen, F., et al., Quercetin/chitosan-graft-alpha lipoic acid micelles: A versatile antioxidant water dispersion with high stability. Carbohydr Polym, 2020. 234: p. 115927.
Sullivan, R., et al., Peripheral Nerve Injury: Stem Cell Therapy and Peripheral Nerve Transfer. Int J Mol Sci, 2016. 17(12).
Bolandghamat, S. and M. Behnam-Rassouli, Recent Findings on the Effects of Pharmacological Agents on the Nerve Re-generation after Peripheral Nerve Injury. Curr Neuropharmacol, 2020. 18(11): p. 1154-1163.
Magani, S.K.J., et al., Salidroside - Can it be a Multifunctional Drug? Curr Drug Metab, 2020. 21(7): p. 512-524.
Li, J., et al., Salidroside promotes sciatic nerve regeneration following combined application epimysium conduit and Schwann cells in rats. Exp Biol Med (Maywood), 2020. 245(6): p. 522-531.
Sheng, Q.S., et al., Salidroside promotes peripheral nerve regeneration following crush injury to the sciatic nerve in rats. Neuroreport, 2013. 24(5): p. 217-23.
Liu, H., et al., The Proliferation Enhancing Effects of Salidroside on Schwann Cells In Vitro. Evid Based Complement Alternat Med, 2017. 2017: p. 4673289.
Liu, H., et al., Salidroside promotes peripheral nerve regeneration based on tissue engineering strategy using Schwann cells and PLGA: in vitro and in vivo. Sci Rep, 2017. 7: p. 39869.
Mandel, S.A., et al., Targeting multiple neurodegenerative diseases etiologies with multimodal-acting green tea catechins. J Nutr, 2008. 138(8): p. 1578s-1583s.
Chen, J., et al., Green Tea Polyphenols Promote Functional Recovery from Peripheral Nerve Injury in Rats. Med Sci Monit, 2020. 26: p. e923806.
Cao, P., et al., Polymeric implants for the delivery of green tea polyphenols. J Pharm Sci, 2014. 103(3): p. 945-51.
Galiniak, S., D. Aebisher, and D. Bartusik-Aebisher, Health benefits of resveratrol administration. Acta Biochim Pol, 2019. 66(1): p. 13-21.
Oda, H., et al., Pretreatment of nerve grafts with resveratrol improves axonal regeneration following replantation surgery for nerve root avulsion injury in rats. Restor Neurol Neurosci, 2018. 36(5): p. 647-658.
Haley, R.M., et al., Resveratrol Delivery from Implanted Cyclodextrin Polymers Provides Sustained Antioxidant Effect on Implanted Neural Probes. Int J Mol Sci, 2020. 21(10).
Ogut, E., et al., Neuroprotective Effects of Ozone Therapy After Sciatic Nerve Cut Injury. Kurume Med J, 2020. 65(4): p. 137-144.
Arruda, H.S., et al., Determination of free, esterified, glycosylated and insoluble-bound phenolics composition in the edible part of araticum fruit (Annona crassiflora Mart.) and its by-products by HPLC-ESI-MS/MS. Food Chem, 2018. 245: p. 738-749.
Venter, A., E. Joubert, and D. de Beer, Characterisation of phenolic compounds in South African plum fruits (Prunus salicina Lindl.) using HPLC coupled with diode-array, fluorescence, mass spectrometry and on-line antioxidant detection. Molecules, 2013. 18(5): p. 5072-90.
Yu, J., et al., Phenolic profiles, bioaccessibility and antioxidant activity of plum (Prunus Salicina Lindl). Food Res Int, 2021. 143: p. 110300.
60. Lin, X., et al., Curcumin attenuates oxidative stress in RAW264.7 cells by increasing the activity of antioxidant en-zymes and activating the Nrf2-Keap1 pathway. PLoS One, 2019. 14(5): p. e0216711.
O'Toole, M.G., et al., Release-Modulated Antioxidant Activity of a Composite Curcumin-Chitosan Polymer. Biomacromol-ecules, 2016. 17(4): p. 1253-60.
Baby, T., et al., Microfluidic synthesis of curcumin loaded polymer nanoparticles with tunable drug loading and pH-triggered release. J Colloid Interface Sci, 2021. 594: p. 474-484.
Hou, X., et al., Poloxamer(188)-based nanoparticles improve the anti-oxidation and anti-degradation of curcumin. Food Chem, 2022. 375: p. 131674.
Hou, Y., et al., A Novel Quinolyl-Substituted Analogue of Resveratrol Inhibits LPS-Induced Inflammatory Responses in Microglial Cells by Blocking the NF-κB/MAPK Signaling Pathways. Mol Nutr Food Res, 2019. 63(20): p. e1801380.
Jiang, H., et al., Resveratrol protects against asthma-induced airway inflammation and remodeling by inhibiting the HMGB1/TLR4/NF-κB pathway. Exp Ther Med, 2019. 18(1): p. 459-466.
Pinheiro, D.M.L., et al., Resveratrol decreases the expression of genes involved in inflammation through transcriptional regulation. Free Radic Biol Med, 2019. 130: p. 8-22.
Jeong, H., et al., Resveratrol cross-linked chitosan loaded with phospholipid for controlled release and antioxidant activity. Int J Biol Macromol, 2016. 93(Pt A): p. 757-766.
Goldberg, S.R. and R.F. Diegelmann, What Makes Wounds Chronic. Surg Clin North Am, 2020. 100(4): p. 681-693.
Huemer, M., et al., Antibiotic resistance and persistence-Implications for human health and treatment perspectives. EMBO Rep, 2020. 21(12): p. e51034.
Khan, F., et al., Caffeic Acid and Its Derivatives: Antimicrobial Drugs toward Microbial Pathogens. J Agric Food Chem, 2021. 69(10): p. 2979-3004.
Kim, J.H., et al., Synergistic Antibacterial Effects of Chitosan-Caffeic Acid Conjugate against Antibiotic-Resistant Ac-ne-Related Bacteria. Mar Drugs, 2017. 15(6).
Renzetti, A., et al., Antibacterial green tea catechins from a molecular perspective: mechanisms of action and struc-ture-activity relationships. Food Funct, 2020. 11(11): p. 9370-9396.
Latos-Brozio, M., A. Masek, and M. Piotrowska, Thermally Stable and Antimicrobial Active Poly(Catechin) Obtained by Reaction with a Cross-Linking Agent. Biomolecules, 2020. 11(1).
Zheng, D., et al., Antibacterial Mechanism of Curcumin: A Review. Chem Biodivers, 2020. 17(8): p. e2000171.
Feng, Y., et al., Tough and biodegradable polyurethane-curcumin composited hydrogel with antioxidant, antibacterial and antitumor properties. Mater Sci Eng C Mater Biol Appl, 2021. 121: p. 111820.
Kachur, K. and Z. Suntres, The antibacterial properties of phenolic isomers, carvacrol and thymol. Crit Rev Food Sci Nutr, 2020. 60(18): p. 3042-3053.
Amato, D.N., et al., Destruction of Opportunistic Pathogens via Polymer Nanoparticle-Mediated Release of Plant-Based Antimicrobial Payloads. Adv Healthc Mater, 2016. 5(9): p. 1094-103.
Nelson, K.M., et al., The Essential Medicinal Chemistry of Curcumin. J Med Chem, 2017. 60(5): p. 1620-1637.
Chen, Y., et al., Nano Encapsulated Curcumin: And Its Potential for Biomedical Applications. Int J Nanomedicine, 2020. 15: p. 3099-3120.
Abdellah, A.M., et al., Green synthesis and biological activity of silver-curcumin nanoconjugates. Future Med Chem, 2018. 10(22): p. 2577-2588.
Monfared, A., A. Ghaee, and S. Ebrahimi-Barough, Preparation and characterisation of zein/polyphenol nanofibres for nerve tissue regeneration. IET Nanobiotechnol, 2019. 13(6): p. 571-577.
de Santana, M.T., et al., Synthesis and pharmacological evaluation of carvacrol propionate. Inflammation, 2014. 37(5): p. 1575-87.
Gharbi, A., et al., Erratum to: Surface functionalization by covalent immobilization of an innovative carvacrol derivative to avoid fungal biofilm formation. AMB Express, 2015. 5(1): p. 141.
Hassib, S.T., et al., Synthesis and biological evaluation of new prodrugs of etodolac and tolfenamic acid with reduced ul-cerogenic potential. Eur J Pharm Sci, 2019. 140: p. 105101.
Latruffe, N. and D. Vervandier-Fasseur, Strategic Syntheses of Vine and Wine Resveratrol Derivatives to Explore their Effects on Cell Functions and Dysfunctions. Diseases, 2018. 6(4).
Nawaz, W., et al., Therapeutic Versatility of Resveratrol Derivatives. Nutrients, 2017. 9(11).
Shi, H., et al., Synthesis of caffeic acid phenethyl ester derivatives, and their cytoprotective and neuritogenic activities in PC12 cells. J Agric Food Chem, 2014. 62(22): p. 5046-53.
Pinho, E., G. Soares, and M. Henriques, Evaluation of antibacterial activity of caffeic acid encapsulated by β-cyclodextrins. J Microencapsul, 2015. 32(8): p. 804-10.
Anwer, M.K., et al., Development and evaluation of PLGA polymer based nanoparticles of quercetin. Int J Biol Macromol, 2016. 92: p. 213-219.
Chen, G., et al., Encapsulation of green tea polyphenol nanospheres in PVA/alginate hydrogel for promoting wound healing of diabetic rats by regulating PI3K/AKT pathway. Mater Sci Eng C Mater Biol Appl, 2020. 110: p. 110686.
Carbone-Howell, A.L., N.D. Stebbins, and K.E. Uhrich, Poly(anhydride-esters) comprised exclusively of naturally occurring antimicrobials and EDTA: antioxidant and antibacterial activities. Biomacromolecules, 2014. 15(5): p. 1889-95.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2022 Biomaterials and Biosensors