The roles of m6A RNA methylation modification in cancer stem cells: new opportunities for cancer suppression


  • Haitao Chen China Pharmaceutical University, China
  • Huilong Li China Pharmaceutical University, China
  • Wanjin Shi China Pharmaceutical University, China
  • Hai Qin Guizhou Provincial Orthopedic Hospital, China
  • Lufeng Zheng China Pharmaceutical University, China



Cancer stem cells, m6A RNA modification, post-transcriptional modification, Stemness, CSC-like traits


As a reversible post-transcriptional modification, N6-methyladeno sine is the most common form of RNA modification in eukaryotic mRNA. Cancer stem cells (CSCs), which are a subpopulation of cells with self-renewal ability and differentiation potential, have been regarded to be one of the roots of tumor occurrence, recurrence, and metastasis. Currently, numerous studies have demonstrated that m6A RNA modification is critically implicated in the regulation of CSCs stemness or the CSC-like traits of cancer cells. This review summarized the effects of m6A RNA modification-related enzymes and underlying mechanisms contributing to CSCs or cancer cell stemness, which may provide novel targets and research directions for the specifical elimination of CSCs or cancer cells with stemness.


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How to Cite

Chen, H., Li, H., Shi, W., Qin, H., & Zheng, L. (2023). The roles of m6A RNA methylation modification in cancer stem cells: new opportunities for cancer suppression. Cancer Insight, 1(2), 1–18.