Therapeutic Effects of Natural Products Isolated from Different Microorganisms in Treating Cervical Cancer: A Review


  • Dipro Mukherjee University of Engineering & Management, India
  • Dibyajit Lahiri University of Engineering & Management, India
  • Moupriya Nag University of Engineering & Management, India



Cyclooxygenase-2 (COX-2); Epidermal growth factor receptor (EGFR); Pelvic lymphadenectomy; Radical hysterectomy; Radiotherapy; Chemotherapy


Cervical cancer is defined as a cancer arising in the cells of cervix that causes unusual vaginal bleeding, discharges, pain in the pelvic region, or pain during sexual activity. Cervical cancer is currently reported to be the fourth most prevalent malignancy among women globally. Surgery includes pelvic lymphadenectomy as well as radical hysterectomy, radiotherapy, as well as chemotherapy are the most common therapies for treating cervical cancer. Another approach includes targeted medication which affects the epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) for the curing cervical cancer. However, these therapies have the potential for risks and complications: surgery can result in bleeding and may cause organ damage surrounding the surgery, and clots may also start to form in the deep veins of the legs; radiotherapy can result in menopause, infertility, discomfort, or pain during intercourse; and chemotherapy can actually impact rapidly dividing cells along with cancer cells in the human body system. In this review, we will discuss about the use of several Randomised controlled trials (RCTs) for treating malnutrition in various oncology patients. In this review, we will discuss about the various therapeutic effects of natural products isolated from different microorganisms in treating cervical cancer.


Urasa, M.; Darj, E. Knowledge of cervical cancer and screening practices of nurses at a regional hospital in Tanzania. Afr. Health Sci. 2011, 11, 48–57. [PubMed]

Bray, F.; Ferlay, J.; Soerjomataram, I.; Siegel, R.L.; Torre, L.A.; Jemal, A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 2018, 68, 394–424. [CrossRef] [PubMed]

Kim, J.Y.; Byun, S.J.; Kim, Y.S.; Nam, J.-H. Disease courses in patients with residual tumor following concurrent chemoradiotherapy for locally advanced cervical cancer. Gynecol. Oncol. 2017, 144, 34–39. [CrossRef] [PubMed]

Hertlein, M.L.; Lenhard, M.; Kirschenhofer, A.; Kahlert, S.; Mayr, D.; Burges, A.; Friese, K. Cetuximab monotherapy in advanced cervical cancer: A retrospective study with five patients. Arch. Gynecol. Obstet. 2011, 283, 109–113. [CrossRef] [PubMed]

Kurtz, J.; Hardy-Bessard, A.-C.; Deslandres, M.; Lavau-Denes, S.; Largillier, R.; Roemer-Becuwe, C.; Weber, B.; Guillemet, C.;

Paraiso, D.; Pujade-Lauraine, E. Cetuximab, topotecan and cisplatin for the treatment of advanced cervical cancer: A phase II GINECO trial. Gynecol. Oncol. 2009, 113, 16–20. [CrossRef]

Gaffney, D.K.; Winter, K.; Dicker, A.P.; Miller, B.; Eifel, P.J.; Ryu, J.; Avizonis, V.; Fromm, M.; Greven, K. A Phase II study of acute toxicity for Celebrex™ (celecoxib. and chemoradiation in patients with locally advanced cervical cancer: Primary endpoint analysis of RTOG. Int. J. Radiat. Oncol. 2007, 67, 104–109. [CrossRef] [PubMed]

Herrera, F.G.; Chan, P.; Doll, C.; Milosevic, M.; Oza, A.; Syed, A.; Pintilie, M.; Levin, W.; Manchul, L.; Fyles, A. A prospective phase I–II trial of the cyclooxygenase-2 inhibitor celecoxib in patients with carcinoma of the cervix with biomarker assessment of the tumor microenvironment. Int. J. Radiat. Oncol. 2007, 67, 97–103. [CrossRef] [PubMed]

Broutet, N.; Eckert, L.; Ullrich, A.; Bloem, P. Comprehensive Cervical Cancer Control: A Guide to Essential Practice; World Health Organization: Geneva, Switzerland, 2014; pp. 1–378.

Lee, J.; Jeong, M.I.; Kim, H.-R.; Park, H.; Moon, W.-K.; Kim, B. Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia. Antioxidants 2020, 9, 836. [CrossRef]

Federico, C.; Sun, J.; Muz, B.; Alhallak, K.; Cosper, P.F.; Muhammad, N.; Jeske, A.; Hinger, A.; Markovina, S.; Grigsby, P.; et al. Localized Delivery of Cisplatin to Cervical Cancer Improves Its Therapeutic Efficacy and Minimizes Its Side-Effect Profile. Int. J. Radiat. Oncol. 2020. [CrossRef]

Shen, D.-W.; Pouliot, L.M.; Hall, M.D.; Gottesman, M.M. Cisplatin Resistance: A Cellular Self-Defense Mechanism Resulting from Multiple Epigenetic and Genetic Changes. Pharmacol. Rev. 2012, 64, 706–721. [CrossRef]

Sun, C.; Brown, A.J.; Jhingran, A.; Frumovitz, M.; Ramondetta, L.; Bodurka, D.C. Patient Preferences for Side Effects Associated With Cervical Cancer Treatment. Int. J. Gynecol. Cancer 2014, 24, 1077–1084. [CrossRef] [PubMed]

Momtazi-Borojeni, A.A.; Ghasemi, F.; Hesari, A.; Majeed, M.; Caraglia, M.; Sahebkar, A. Anti-Cancer and Radio-Sensitizing Effects of Curcumin in Nasopharyngeal Carcinoma. Curr. Pharm. Des. 2018, 24, 2121–2128. [CrossRef] [PubMed]

Nasreen, S.; Safeer, S.; Dar, K.K.; Andleeb, S.; Ejaz, M.; Khan, M.A.; Ali, S. Etiology of hepatocellular carcinoma and treatment through medicinal plants: A comprehensive review. Orient. Pharm. Exp. Med. 2018, 18, 187–197. [CrossRef]

Ezzat, S.M.; Shouman, S.A.; ElKhoely, A.; Attia, Y.M.; Elsesy, M.E.; El Senousy, A.S.; Choucry, M.A.; El Gayed, S.H.; El Sayed, A.A.; Sattar, E.A.; et al. Anticancer potentiality of lignan rich fraction of six Flaxseed cultivars. Sci. Rep. 2018, 8, 544. [CrossRef]


Hong, B.; Li, J.; Huang, C.; Huang, T.; Zhang, M.; Huang, L. miR-300/FA2H affects gastric cancer cell proliferation and apoptosis. Open Med. 2020, 15, 882–889. [CrossRef]

Escuin, D.; López-Vilaró, L.; Bell, O.; Mora, J.; Moral, A.; Pérez, J.I.; Arqueros, C.; Cajal, T.R.Y.; Lerma, E.; Barnadas, A. MicroRNA1291 Is Associated With Locoregional Metastases in Patients With Early-Stage Breast Cancer. Front. Genet. 2020, 11, 562114. [CrossRef]

Lim, H.J.; Park, M.N.; Kim, C.; Kang, B.; Song, H.-S.; Lee, H.; Kim, S.-H.; Shim, B.S.; Kim, B. MiR-657/ATF2 Signaling Pathway Has a Critical Role in Spatholobus suberectus Dunn Extract-Induced Apoptosis in U266 and U937 Cells. Cancers 2019, 11, 150. [CrossRef]

Kim, C.; Song, H.-S.; Park, H.; Kim, B. Activation of ER Stress-Dependent miR-216b Has a Critical Role in Salvia miltiorrhiza Ethanol-Extract-Induced Apoptosis in U266 and U937 Cells. Int. J. Mol. Sci. 2018, 19, 1240. [CrossRef]

Phuah, N.H.; Azmi, M.N.; Awang, K.; Nagoor, N.H. Down-Regulation of MicroRNA-210 Confers Sensitivity towards 1’S-1’Acetoxychavicol Acetate (ACA. in Cervical Cancer Cells by Targeting SMAD. Mol. Cells 2017, 40, 291–298. [CrossRef]

Noh, S.; Choi, E.; Hwang, C.-H.; Jung, J.H.; Kim, S.-H.; Kim, B. Dietary Compounds for Targeting Prostate Cancer. Nutritients 2019, 11, 2401. [CrossRef]

Lowe, S.W.; Lin, A.W. Apoptosis in cancer. Carcinog. 2000, 21, 485–495. [CrossRef]

Li, F.-Y.; Wang, X.; Duan, W.-G.; Lin, G.-S. Synthesis and In Vitro Anticancer Activity of Novel Dehydroabietic Acid-Based Acylhydrazones. Molecules 2017, 22, 1087. [CrossRef] [PubMed]

Vishnu, V.R.; Renjith, R.S.; Mukherjee, A.; Anil, S.R.; Sreekumar, J.; Jyothi, A.N.; Alummoottil, J.N. Comparative Study on the Chemical Structure and In Vitro Antiproliferative Activity of Anthocyanins in Purple Root Tubers and Leaves of Sweet Potato (Ipomoea batatas.. J. Agric. Food Chem. 2019, 67, 2467–2475. [CrossRef] [PubMed]

Piboonprai, K.; Khumkhrong, P.; Khongkow, M.; Yata, T.; Ruangrungsi, N.; Chansriniyom, C.; Iempridee, T. Anticancer activity of arborinine from Glycosmis parva leaf extract in human cervical cancer cells. Biochem. Biophys. Res. Commun. 2018, 500, 866–872. [CrossRef] [PubMed]

Wang, L.; Zhao, Y.; Wu, Q.; Guan, Y.; Wu, X. Therapeutic effects of β-elemene via attenuation of the Wnt/β-catenin signaling pathway in cervical cancer cells. Mol. Med. Rep. 2018, 17, 4299–4306. [CrossRef] [PubMed]

Rehana, D.; Mahendiran, D.; Kumar, R.S.; Rahiman, A.K. Evaluation of antioxidant and anticancer activity of copper oxide nanoparticles synthesized using medicinally important plant extracts. Biomed. Pharmacother. 2017, 89, 1067–1077. [CrossRef]

Wang, J.; Liu, Q.; Yang, L.; Xia, X.; Zhu, R.; Chen, S.; Wang, M.; Cheng, L.; Wu, X.; Wang, S. Curcumin-Loaded TPGS/F127/P123 Mixed Polymeric Micelles for Cervical Cancer Therapy: Formulation, Characterization, and In Vitro and In Vivo Evaluation.

J. Biomed. Nanotechnol. 2017, 13, 1631–1646. [CrossRef]

Moreira, T.F.; Sorbo, J.M.; Souza, F.D.O.; Fernandes, B.C.; Ocampos, F.M.M.; De Oliveira, D.M.S.; Arcaro, C.A.; Assis, R.P.; Barison,

A.; Miguel, O.G.; et al. Emodin, Physcion, and Crude Extract of Rhamnus sphaerosperma var. pubescens Induce Mixed Cell Death, Increase in Oxidative Stress, DNA Damage, and Inhibition of AKT in Cervical and Oral Squamous Carcinoma Cell Lines. Oxidative Med. Cell. Longev. 2018, 2018, 1–18. [CrossRef]

Yang, J.; Fa, J.; Li, B. Apoptosis induction of epifriedelinol on human cervical cancer cell line. Afr. J. Tradit. Complement. Altern. Med. 2017, 14, 80–86. [CrossRef]

Das, A.; Harshadha, K.; Dhinesh Kannan, S.; Hari Raj, K.; Jayaprakash, B. Evaluation of therapeutic potential of eugenol-a natural derivative of Syzygium aromaticum on cervical cancer. APJCP 2018, 19, 1977.

Chen, X.; Song, L.; Hou, Y.; Li, F. Reactive oxygen species induced by icaritin promote DNA strand breaks and apoptosis in human cervical cancer cells. Oncol. Rep. 2018, 41, 765–778. [CrossRef] [PubMed]

Kuo, C.-Y.; Schelz, Z.; Tóth, B.; Vasas, A.; Ocsovszki, I.; Chang, F.-R.; Hohmann, J.; Zupkó, I.; Wang, H.-C. Investigation of natural phenanthrenes and the antiproliferative potential of juncusol in cervical cancer cell lines. Phytomedicine 2018, 58, 152770. [CrossRef] [PubMed]

Ma, Y.-L.; Zhang, Y.-S.; Zhang, F.; Zhang, Y.-Y.; Thakur, K.; Zhang, J.-G.; Wei, Z.-J. Methyl protodioscin from Polygonatum sibiricum inhibits cervical cancer through cell cycle arrest and apoptosis induction. Food Chem. Toxicol. 2019, 132, 110655. [CrossRef]

Al-Otaibi, W.A.; Alkhatib, M.H.; Wali, A.N. Cytotoxicity and apoptosis enhancement in breast and cervical cancer cells upon coadministration of mitomycin C and essential oils in nanoemulsion formulations. Biomed. Pharmacother. 2018, 106, 946–955. [CrossRef]

Latif, A.D.; Gonda, T.; Vágvölgyi, M.; Kúsz, N.; Kulmány, Á.; Ocsovszki, I.; Zomborszki, Z.P.; Zupkó, I.; Hunyadi, A. Synthesis and In Vitro Antitumor Activity of Naringenin Oxime and Oxime Ether Derivatives. Int. J. Mol. Sci. 2019, 20, 2184. [CrossRef]

Souza, F.D.O.; Sorbo, J.M.; Regasini, L.O.; Rosa, J.C.; Czernys, É.D.S.; Valente, V.; Moreira, T.F.; Navegante, G.; Fernandes, B.C.; Soares, C.P. Nitensidine B affects proteins of the glycolytic pathway and induces apoptosis in cervical carcinoma cells immortalized by HPV. Phytomedicine 2018, 48, 179–186. [CrossRef] [PubMed]

Li, L.; Sun, J.-X.; Wang, X.-Q.; Liu, X.-K.; Chen, X.-X.; Zhang, B.; He, Z.-D.; Liu, D.-Z.; Chen, L.-X.; Wang, L.-W.; et al. Notoginsenoside R7 suppresses cervical cancer via PI3K/PTEN/Akt/mTOR signaling. Oncotarget 2017, 8, 109487–109496. [CrossRef]

Che, Y.; Li, J.; Li, Z.; Li, J.; Wang, S.; Yan, Y.; Zou, K.; Zou, L. Osthole enhances antitumor activity and irradiation sensitivity of cervical cancer cells by suppressing ATM/NF-κB signaling. Oncol. Rep. 2018, 40, 737–747. [CrossRef]

Selvan, D.A.; Mahendiran, D.; Kumar, R.S.; Rahiman, A.K. Garlic, green tea and turmeric extracts-mediated green synthesis of silver nanoparticles: Phytochemical, antioxidant and in vitro cytotoxicity studies. J. Photochem. Photobiol. B Biol. 2018, 180, 243–252. [CrossRef]

Xie, Z.; Wei, Y.; Xu, J.; Lei, J.; Yu, J. Alkaloids from Piper nigrum Synergistically Enhanced the Effect of Paclitaxel against Paclitaxel-Resistant Cervical Cancer Cells through the Downregulation of Mcl-1. J. Agric. Food Chem. 2019, 67, 5159–5168. [CrossRef]

Zhang, Y.; Zhou, D.; Liu, W.; Li, C.; Hao, L.; Zhang, G.; Deng, S.; Yang, R.; Qin, J.K.; Li, J.; et al. Cytotoxic Activity and Related Mechanisms of Prenylflavonoids Isolated from Mallotus conspurcatus Croizat. Chem. Biodivers. 2019, 16, e1800465. [CrossRef]


Lin, C.-L.; Lee, C.-H.; Chen, C.-M.; Cheng, C.-W.; Chen, P.-N.; Ying, T.-H.; Hsieh, Y.-H. Protodioscin induces apoptosis through ROS-mediated endoplasmic reticulum stress via the JNK/p38 activation pathways in human cervical cancer cells. Cell. Physiol. Biochem. 2018, 46, 322–334. [CrossRef] [PubMed]

Chatterjee, K.; Mukherjee, S.; Vanmanen, J.; Banerjee, P.; Fata, J.E. Dietary Polyphenols, Resveratrol and Pterostilbene Exhibit Antitumor Activity on an HPV E6-Positive Cervical Cancer Model: An in vitro and in vivo Analysis. Front. Oncol. 2019, 9, 352. [CrossRef] [PubMed]

Chen, Y.; Qu, D.; Fu, R.; Guo, M.; Qin, Y.; Guo, J.; Chen, Y. A Tf-modified tripterine-loaded coix seed oil microemulsion enhances anti-cervical cancer treatment. Int. J. Nanomed. 2018, 13, 7275–7287. [CrossRef] [PubMed]

Li, J.; Khan, A.; Wei, C.; Cheng, J.; Chen, H.; Yang, L.; Ijaz, I.; Fu, J. Thymoquinone Inhibits the Migration and Invasive Characteristics of Cervical Cancer Cells SiHa and CaSki In Vitro by Targeting Epithelial to Mesenchymal Transition Associated Transcription Factors Twist1 and Zeb1. Molecules 2017, 22, 2105. [CrossRef] [PubMed]

Zhao, Y.; Wang, M.; Tsering, J.; Li, H.; Li, S.; Li, Y.; Liu, Y.; Hu, X. An Integrated Study on the Antitumor Effect and Mechanism of Triphala Against Gynecological Cancers Based on Network Pharmacological Prediction and In Vitro Experimental Validation. Integr. Cancer Ther. 2018, 17, 894–901. [CrossRef] [PubMed]

Phuah, N.H.; Azmi, M.N.; Awang, K.; Nagoor, N.H. Suppression of microRNA-629 enhances sensitivity of cervical cancer cells to 10S-10-acetoxychavicol acetate via regulating RSU1. OncoTargets Ther. 2017, 10, 1695–1705. [CrossRef] [PubMed]

Wang, R.; Yang, W.; Fan, Y.; Dehaen, W.; Li, Y.; Li, H.-J.; Wang, W.; Zheng, Q.; Huai, Q.-Y. Design and synthesis of the novel oleanolic acid-cinnamic acid ester derivatives and glycyrrhetinic acid-cinnamic acid ester derivatives with cytotoxic properties. Bioorganic Chem. 2019, 88, 102951. [CrossRef]

Hassan, A.H.; Choi, E.; Yoon, Y.M.; Lee, K.W.; Yoo, S.Y.; Cho, M.C.; Yang, J.S.; Kim, H.I.; Hong, J.Y.; Shin, J.-S.; et al. Natural products hybrids: 3,5,4’-Trimethoxystilbene-5,6,7-trimethoxyflavone chimeric analogs as potential cytotoxic agents against diverse human cancer cells. Eur. J. Med. Chem. 2018, 161, 559–580. [CrossRef]

Fan, Y.; Zhang, Y.; Liu, Y.; Xu, W.; Yang, Y.; Hao, Y.; Tao, L. A natural product enhances apoptosis via mitochondria/caspasemediated pathway in HeLa cells. J. Cell. Biochem. 2019, 120, 16811–16823. [CrossRef]

Fiandalo, M.; Kyprianou, N. Caspase control: Protagonists of cancer cell apoptosis. Exp. Oncol. 2012, 34, 165–175. [PubMed] 53. Kang, M.H.; Reynolds, C.P. Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy. Clin. Cancer Res. 2009, 15, 1126–1132. [CrossRef] [PubMed]

Huh, W.K.; Gomez-Navarro, J.; Arafat, W.O.; Xiang, J.; Mahasreshti, P.J.; Alvarez, R.D.; Barnes, M.N.; Curiel, D.T. Bax-Induced Apoptosis as a Novel Gene Therapy Approach for Carcinoma of the Cervix. Gynecol. Oncol. 2001, 83, 370–377. [CrossRef] [PubMed]

Swanepoel, B.; Venables, L.; Octavian-Tudorel, O.; Nitulescu, G.M.; Van De Venter, M. In Vitro Anti-proliferative Activity and Mechanism of Action of Anemone nemorosa. Int. J. Mol. Sci. 2019, 20, 1217. [CrossRef]

Dwarka, D.; Thaver, V.; Naidu, M.; Koorbanally, N.A.; Baijnath, A.H. In vitro chemo-preventative activity of strelitzia nicolai aril extract containing bilirubin. Afr. J. Tradit. Complement. Altern. Med. 2017, 14, 147–156. [CrossRef]

Lee, K.M.; Lee, K.; Choi, Y.K.; Choi, Y.J.; Seo, H.S.; Ko, S.G. SH003-induced G1 phase cell cycle arrest induces apoptosis in HeLa cervical cancer cells. Mol. Med. Rep. 2017, 16, 8237–8244. [CrossRef]

Dos Santos, K.M.; Gomes, I.N.F.; Silva-Oliveira, R.J.; Pinto, F.E.; Oliveira, B.G.; Chagas, R.C.R.; Romão, W.; Reis, R.M.; Ribeiro, R.I.M.D.A. Bauhinia variegata candida Fraction Induces Tumor Cell Death by Activation of Caspase-3, RIP, and TNF-R1 and Inhibits Cell Migration and Invasion In Vitro. BioMed Res. Int. 2018, 2018, 1–10. [CrossRef]

Suh, S.-S.; Kim, S.-M.; Kim, J.E.; Hong, J.-M.; Lee, S.G.; Youn, U.J.; Han, S.J.; Kim, I.C.; Kim, S. Anticancer activities of ethanol extract from the Antarctic freshwater microalga, Botryidiopsidaceae sp. BMC Complement. Altern. Med. 2017, 17, 509. [CrossRef]

Suh, S.-S.; Yang, E.J.; Lee, S.G.; Youn, U.J.; Han, S.J.; Kim, I.-C.; Kim, S. Bioactivities of ethanol extract from the Antarctic freshwater microalga, Chloromonas sp. Int. J. Med Sci. 2017, 14, 560–569. [CrossRef]

Prasad, R.; Rana, N.K.; Koch, B. Dendrobium chrysanthum ethanolic extract induces apoptosis via p53 up-regulation in HeLa cells and inhibits tumor progression in mice. J. Complement. Integr. Med. 2017, 14, 14. [CrossRef]

Ma, J.F.; Wei, P.F.; Guo, C.; Shi, Y.P.; Lv, Y.; Qiu, L.X.; Wen, L.P. The Ethyl Acetate Extract of Gynura formosana Kitam. Leaves Inhibited Cervical Cancer Cell Proliferation via Induction of Autophagy. BioMed Res. Int. 2018, 2018, 1–10. [CrossRef]

Kuriakose, G.C.; M, D.L.; Bp, A.; Rs, H.K.; Th, A.K.; Ananthaswamy, K.; Chelliah, J. Extract of Penicillium sclerotiorum an endophytic fungus isolated from Cassia fistula L. induces cell cycle arrest leading to apoptosis through mitochondrial membrane depolarization in human cervical cancer cells. Biomed. Pharmacother. 2018, 105, 1062–1071. [CrossRef] [PubMed]

Dan, V.M.; Muralikrishnan, B.; Sanawar, R.; S, V.J.; Burkul, B.B.; Srinivas, K.P.; Lekshmi, A.; Pradeep, N.S.; Dastager, S.G.; Santhakumari, B.; et al. Streptomyces sp. metabolite(s. promotes Bax mediated intrinsic apoptosis and autophagy involving inhibition of mTOR pathway in cervical cancer cell lines. Sci. Rep. 2018, 8, 2810. [CrossRef] [PubMed]

Davidson, K.T.; Zhu, Z.; Bai, Q.; Xiao, H.; Wakefield, M.R.; Fang, Y. Blueberry as a Potential Radiosensitizer for Treating Cervical Cancer. Pathol. Oncol. Res. 2019, 25, 81–88. [CrossRef] [PubMed]

Huang, H.; Zhang, M.; Yao, S.; Zhang, M.; Peng, J.; Guiling with the Pinellia Pedatisecta (PE. Advisory Group; Xu, C.-J.; Ye, Y.; Gui, S. Immune modulation of a lipid-soluble extract of Pinellia pedatisecta Schott in the tumor microenvironment of an HPV + tumor-burdened mouse model. J. Ethnopharmacol. 2018, 225, 103–115. [CrossRef] [PubMed]

Khazaei, S.; Ramachandran, V.; Hamid, R.A.; Esa, N.M.; Etemad, A.; Moradipoor, S.; Patimah, I. Flower extract of Allium atroviolaceum triggered apoptosis, activated caspase-3 and down-regulated antiapoptotic Bcl-2 gene in HeLa cancer cell line. Biomed. Pharmacother. 2017, 89, 1216–1226. [CrossRef] [PubMed]

Esposito, T.; Sansone, F.; Franceschelli, S.; Del Gaudio, P.; Picerno, P.; Aquino, R.P.; Mencherini, T. Hazelnut (Corylus avellana L.. Shells Extract: Phenolic Composition, Antioxidant Effect and Cytotoxic Activity on Human Cancer Cell Lines. Int. J. Mol. Sci. 2017, 18, 392. [CrossRef]

Mannarreddy, P.; Denis, M.; Munireddy, D.; Pandurangan, R.; Thangavelu, K.P.; Venkatesan, K. Cytotoxic effect of Cyperus rotundus rhizome extract on human cancer cell lines. Biomed. Pharmacother. 2017, 95, 1375–1387. [CrossRef]

Vijayarathna, S.; Chen, Y.; Kanwar, J.R.; Sasidharan, S. Standardized Polyalthia longifolia leaf extract (PLME. inhibits cell proliferation and promotes apoptosis: The anti-cancer study with various microscopy methods. Biomed. Pharmacother. 2017, 91, 366–377. [CrossRef]

Sul‘ain, M.D.; Fashihah Zakaria, M.F.J. Anti-Proliferative Effects of Methanol and Water Extracts of Pyrrosia piloselloides on the Hela Human Cervical Carcinoma Cell Line. APJCP 2019, 20, 185.

Panicker, N.G.; Balhamar, S.O.M.S.; Akhlaq, S.; Qureshi, M.M.; Rizvi, T.S.; Al-Harrasi, A.; Hussain, J.; Mustafa, F. Identification and Characterization of the Caspase-Mediated Apoptotic Activity of Teucrium mascatense and an Isolated Compound in Human Cancer Cells. Molecules 2019, 24, 977. [CrossRef] [PubMed]

Lord, C.J.; Ashworth, A. Targeted therapy for cancer using PARP inhibitors. Curr. Opin. Pharmacol. 2008, 8, 363–369. [CrossRef] [PubMed]

Ma, J.; Waxman, D.J. Combination of antiangiogenesis with chemotherapy for more effective cancer treatment. Mol. Cancer Ther. 2008, 7, 3670–3684. [CrossRef]

Rajabi, M.; Mousa, S.A. The Role of Angiogenesis in Cancer Treatment. Biomediences 2017, 5, 34. [CrossRef] [PubMed]

Tomao, S.; Tomao, F.; Rossi, L.; Zaccarelli, E.; Caruso, D.; Zoratto, F.; Panici, P.B.; Papa, A. Angiogenesis and antiangiogenic agents in cervical cancer. OncoTargets Ther. 2014, 7, 2237–2248. [CrossRef] [PubMed]

Shivamadhu, M.C.; Srinivas, B.K.; Jayarama, S.; Chandrashekaraiah, S.A. Anti-cancer and anti-angiogenic effects of partially purified lectin from Praecitrullus fistulosus fruit on in vitro and in vivo model. Biomed. Pharmacother. 2017, 96, 1299–1309. [CrossRef]

Seifaddinipour, M.; Farghadani, R.; Namvar, F.; Bin Mohamad, J.; Kadir, H.A. Cytotoxic Effects and Anti-Angiogenesis Potential of Pistachio (Pistacia vera L.. Hulls against MCF-7 Human Breast Cancer Cells. Molecules 2018, 23, 110. [CrossRef]

Foda, H.D.; Zucker, S. Matrix metalloproteinases in cancer invasion, metastasis and angiogenesis. Drug Discov. Today 2001, 6, 478–482. [CrossRef]

Weber, G.F. Why does cancer therapy lack effective anti-metastasis drugs? Cancer Lett. 2013, 328, 207–211. [CrossRef]

Chanvorachote, P.; Chamni, S.; Ninsontia, C.; Phiboonchaiyanan, P.P. Potential Anti-metastasis Natural Compounds for Lung Cancer. Anticancer Res. 2016, 36, 5707–5718. [CrossRef]

Zhang, L.; Zhou, J.; Qin, X.; Huang, H.; Nie, C. Astragaloside IV inhibits the invasion and metastasis of SiHa cervical cancer cells via the TGF-β1-mediated PI3K and MAPK pathways. Oncol. Rep. 2019, 41, 2975–2986. [CrossRef] [PubMed]

Wang, Y.-Q.; Lu, J.-L.; Liang, Y.-R.; Li, Q.-S. Suppressive Effects of EGCG on Cervical Cancer. Molecules 2018, 23, 2334. [CrossRef] [PubMed]

Hung, C.-Y.; Lee, C.-H.; Chiou, H.-L.; Lin, C.-L.; Chen, P.-N.; Lin, M.-T.; Hsieh, Y.-H.; Chou, M.-C. Praeruptorin-b inhibits 12-otetradecanoylphorbol-13-acetate-induced cell invasion by targeting akt/nf-kappab via matrix metalloproteinase-2/-9 expression in human cervical cancer cells. Cell Physiol. Biochem. 2019, 52, 1255–1266. [PubMed]

Lee, C.-Y.; Yang, S.-F.; Wang, P.-H.; Su, C.-W.; Hsu, H.-F.; Tsai, H.-T.; Hsiao, Y.-H. Antimetastatic effects of Terminalia catappa leaf extracts on cervical cancer through the inhibition of matrix metalloprotein-9 and MAPK pathway. Environ. Toxicol. 2019, 34, 60–66. [CrossRef]

Onder, T.T.; Gupta, P.B.; Mani, S.A.; Yang, J.; Lander, E.S.; Weinberg, R.A. Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways. Cancer Res. 2008, 68, 3645–3654. [CrossRef]

Vasan, N.; Baselga, J.; Hyman, D.M. A view on drug resistance in cancer. Nat. Cell Biol. 2019, 575, 299–309. [CrossRef]

Gillet, J.-P.; Gottesman, M.M. Mechanisms of Multidrug Resistance in Cancer. In cryoEM; Springer Science and Business Media LLC: Berlin, Germany, 2010; Volume 596, pp. 47–76.

Faustino, C.; Neto, Í.; Fonte, P.; Macedo, A. Cytotoxicity and Chemotherapeutic Potential of Natural Rosin Abietane Diterpenoids and their Synthetic Derivatives. Curr. Pharm. Des. 2018, 24, 4362–4375. [CrossRef]

Levrier, C.; Rockstroh, A.; Gabrielli, B.; Kavallaris, M.; Lehman, M.; Davis, R.A.; Sadowski, M.C.; Nelson, C. Discovery of thalicthuberine as a novel antimitotic agent from nature that disrupts microtubule dynamics and induces apoptosis in prostate cancer cells. Cell Cycle 2018, 17, 652–668. [CrossRef]

Levrier, C.; Sadowski, M.C.; Rockstroh, A.; Gabrielli, B.; Kavallaris, M.; Lehman, M.; Davis, R.A.; Nelson, C. 6α-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells. Mol. Cancer Ther. 2016, 16, 3–15. [CrossRef]

Ho, C.S.; Yap, S.H.; Phuah, N.H.; In, L.L.; Nagoor, N.H. MicroRNAs associated with tumour migration, invasion and angiogenic properties in A549 and SK-Lu1 human lung adenocarcinoma cells. Lung Cancer 2014, 83, 154–162. [CrossRef]

Di Leva, G.; Croce, C.M. miRNA profiling of cancer. Curr. Opin. Genet. Dev. 2013, 23, 3–11. [CrossRef] [PubMed]

Wu, S.; Huang, S.; Ding, J.; Zhao, Y.; Liang, L.; Liu, T.; Zhan, R.; He, X. Multiple microRNAs modulate p21Cip1/Waf1 expression by directly targeting its 30 untranslated region. Oncogene 2010, 29, 2302–2308. [CrossRef] [PubMed]

Reddy, K.B. MicroRNA (miRNA. in cancer. Cancer Cell Int. 2015, 15, 1–6. [CrossRef] [PubMed]

de Moura, M.D.; de Se Silva, J.; de Oliveira, R.A.G.; de Diniz, M.; Barbosa-Filho, J.M. Natural products reported as potential inhibitors of uterine cervical neoplasia. Acta Farm. Bonaer. 2002, 21, 67–74.

AL, A.O. Dietary supplements as a treatment for cervical cancer: A systematic review. Nutr. Hosp. 2013, 28, 1770–1780.

Wang, S.; Zheng, C.; Peng, C.; Zhang, H.; Jiang, Y.-P.; Han, T.; Qin, L.-P. Plants and cervical cancer: An overview. Expert Opin. Investig. Drugs 2013, 22, 1133–1156. [CrossRef]

Roy, M.; Mukherjee, A.; Sarkar, R.; Mukherjee, S.; Biswas, J. In Search of Natural Remediation for Cervical Cancer. Anti-Cancer Agents Med. Chem. 2014, 15, 57–65. [CrossRef]




How to Cite

Mukherjee, D. ., Lahiri , D., & Nag, M. . (2023). Therapeutic Effects of Natural Products Isolated from Different Microorganisms in Treating Cervical Cancer: A Review. Cancer Insight, 1(2), 31–46.