Recent Progress in the Transition Metal Sulfide/Phosphide for Cancer Theranostic Applications


  • Xingru Zhao Beijing CapitalBio Technology Co., Ltd; University of Science and Technology of China, China
  • Qi An Tsinghua University, China
  • Jingwen Cai University of Science and Technology of China, China



Transition metal sulfides; Transition metal phosphides; Nanomedicine; Drug delivery; Cancer diagnosis and therapy


Transition metal sulfides/transition metal phosphides (TMS/TMP) has shown great potential in cancer diagnosis and treatment due to its unique structural, optical, acoustic and magnetic properties. TMS/TMP can be formed from sulfur/phosphorus source and metal into binary compounds, or from the interaction of hydrogen sulfide (or hydrogen sulfuric acid) with metal oxides or hydroxides. It has a series of unique properties, such as high conductivity, metalloid properties, a variety of valence states and adjustable structure and so on. These advantages make it have great potential in biomedical applications, such as diagnostic imaging, disease therapy and drug/gene delivery. This review presents the latest research progress of TMS/TMP on tumor imaging, diagnosis and treatment. Here, we first illustrate the synthesis approaches and surface modification of TMS/TMP. Then, its emerging applications in tumor diagnosis and therapy are highlighted. Moreover, the challenges of TMS/TMP-mediated diagnosis/treat are provided and the prospective for this field are discussed.


Li, L.; Chen, C.; Liu, H.; Fu, C.; Tan, L.; Wang, S.; Fu, S.; Liu, X.; Meng, X.; Liu, H. Multifunctional Carbon-Silica Nanocapsules with Gold Core for Synergistic Photothermal and Chemo-Cancer Therapy under the Guidance of Bimodal Imaging. Adv. Funct. Mater. 2016, 26, 4252-4261.

Song, Y. Y.; Li, C.; Yang, X. Q.; An, J.; Cheng, K.; Xuan, Y.; Shi, X. M.; Gao, M. J.; Song, X. L.; Zhao, Y. D.; Chen, W. Graphene oxide coating core-shell silver sulfide@mesoporous silica for active targeted dual-mode imaging and chemo-photothermal synergistic therapy against tumors. J Mater Chem B 2018, 6, 4808-4820.

Durgadas, C. V.; Sreenivasan, K.; Sharma, C. P. Bright blue emitting CuSe/ZnS/silica core/shell/shell quantum dots and their biocompatibility. Biomaterials 2012, 33, 6420-6429.

Ma, B.; Wang, S.; Liu, F.; Zhang, S.; Duan, J.; Li, Z.; Kong, Y.; Sang, Y.; Liu, H.; Bu, W.; Li, L. Self-Assembled Copper-Amino Acid Nanoparticles for in Situ Glutathione "AND" H2O2 Sequentially Triggered Chemodynamic Therapy. J. Am. Chem. Soc. 2019, 141, 849-857.

Li, L.; Guan, Y.; Liu, H.; Hao, N.; Liu, T.; Meng, X.; Fu, C.; Li, Y.; Qu, Q.; Zhang, Y.; Ji, S.; Chen, L.; Chen, D.; Tang, F. Silica nanorattle-doxorubicin-anchored mesenchymal stem cells for tumor-tropic therapy. ACS Nano 2011, 5, 7462-70.

Zhang, Y.; Zhao, N.; Qin, Y.; Wu, F.; Xu, Z.; Lan, T.; Cheng, Z.; Zhao, P.; Liu, H. Affibody-functionalized Ag2S quantum dots for photoacoustic imaging of epidermal growth factor receptor overexpressed tumors. Nanoscale 2018, 10, 16581-16590.

Meng, Z.; Wei, F.; Ma, W.; Yu, N.; Wei, P.; Wang, Z.; Tang, Y.; Chen, Z.; Wang, H.; Zhu, M. Design and Synthesis of “All-in-One” Multifunctional FeS2Nanoparticles for Magnetic Resonance and Near-Infrared Imaging Guided Photothermal Therapy of Tumors. Advanced Functional Materials 2016, 26, 8231-8242.

Zhang, Y.; Zhang, Y.; Hong, G.; He, W.; Zhou, K.; Yang, K.; Li, F.; Chen, G.; Liu, Z.; Dai, H.; Wang, Q. Biodistribution, pharmacokinetics and toxicology of Ag2S near-infrared quantum dots in mice. Biomaterials 2013, 34, 3639-46.

Qu, A.; Xu, L.; Sun, M.; Liu, L.; Kuang, H.; Xu, C. Photoactive Hybrid AuNR-Pt@Ag2S Core-Satellite Nanostructures for Near-Infrared Quantitive Cell Imaging. Advanced Functional Materials 2017, 27.

Yang, T.; Tang, Y.; Liu, L.; Lv, X.; Wang, Q.; Ke, H.; Deng, Y.; Yang, H.; Yang, X.; Liu, G.; Zhao, Y.; Chen, H. Size-Dependent Ag2S Nanodots for Second Near-Infrared Fluorescence/Photoacoustics Imaging and Simultaneous Photothermal Therapy. ACS Nano 2017, 11, 1848-1857.

Wang, G.; Liu, J.; Zhu, L.; Ma, X.; Wang, X.; Yang, X.; Guo, Y.; Yang, L.; Lu, J. Self-Destruction of Cancer Induced by Ag2 S Amorphous Nanodots. Small 2019, 15, e1902945.

Liu, T.; Chao, Y.; Gao, M.; Liang, C.; Chen, Q.; Song, G.; Cheng, L.; Liu, Z. Ultra-small MoS2 nanodots with rapid body clearance for photothermal cancer therapy. Nano Research 2016, 9, 3003-3017.

Meng, X.; Liu, Z.; Cao, Y.; Dai, W.; Zhang, K.; Dong, H.; Feng, X.; Zhang, X. Fabricating Aptamer-Conjugated PEGylated-MoS2


S Theranostic Nanoplatform for Multiplexed Imaging Diagnosis and Chemo-Photothermal Therapy of Cancer. Advanced Functional Materials 2017, 27.

Wang, S.; Chen, Y.; Li, X.; Gao, W.; Zhang, L.; Liu, J.; Zheng, Y.; Chen, H.; Shi, J. Injectable 2D MoS2 -Integrated Drug Delivering Implant for Highly Efficient NIR-Triggered Synergistic Tumor Hyperthermia. Adv Mater 2015, 27, 7117-22.

Chang, M.; Wang, M.; Wang, M.; Shu, M.; Ding, B.; Li, C.; Pang, M.; Cui, S.; Hou, Z.; Lin, J. A Multifunctional Cascade Bioreactor Based on Hollow‐Structured Cu2MoS4 for Synergetic Cancer Chemo‐Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy. Adv. Mater. 2019, 31.

Goel, S.; Ferreira, C. A.; Chen, F.; Ellison, P. A.; Siamof, C. M.; Barnhart, T. E.; Cai, W. Activatable Hybrid Nanotheranostics for Tetramodal Imaging and Synergistic Photothermal/Photodynamic Therapy. Adv Mater 2018, 30.

Gu, X.; Qiu, Y.; Lin, M.; Cui, K.; Chen, G.; Chen, Y.; Fan, C.; Zhang, Y.; Xu, L.; Chen, H.; Wan, J. B.; Lu, W.; Xiao, Z. CuS Nanoparticles as a Photodynamic Nanoswitch for Abrogating Bypass Signaling To Overcome Gefitinib Resistance. Nano Lett 2019, 19, 3344-3352.

Wu, Z.-C.; Li, W.-P.; Luo, C.-H.; Su, C.-H.; Yeh, C.-S. Rattle-Type Fe3O4@CuS Developed to Conduct Magnetically Guided Photoinduced Hyperthermia at First and Second NIR Biological Windows. Advanced Functional Materials 2015, 25, 6527-6537.

Liang, S.; Deng, X.; Chang, Y.; Sun, C.; Shao, S.; Xie, Z.; Xiao, X.; Ma, P.; Zhang, H.; Cheng, Z.; Lin, J. Intelligent Hollow Pt-CuS Janus Architecture for Synergistic Catalysis-Enhanced Sonodynamic and Photothermal Cancer Therapy. Nano Lett 2019, 19, 4134-4145.

Hu, R.; Fang, Y.; Huo, M.; Yao, H.; Wang, C.; Chen, Y.; Wu, R. Ultrasmall Cu2-xS nanodots as photothermal-enhanced Fenton nanocatalysts for synergistic tumor therapy at NIR-II biowindow. Biomaterials 2019, 206, 101-114.

Ji, J.; Ma, F.; Zhang, H.; Liu, F.; He, J.; Li, W.; Xie, T.; Zhong, D.; Zhang, T.; Tian, M.; Zhang, H.; Santos, H. A.; Zhou, M. Light-Activatable Assembled Nanoparticles to Improve Tumor Penetration and Eradicate Metastasis in Triple Negative Breast Cancer. Advanced Functional Materials 2018, 28.

Yang, G.; Gong, H.; Liu, T.; Sun, X.; Cheng, L.; Liu, Z. Two-dimensional magnetic WS2@Fe3O4 nanocomposite with mesoporous silica coating for drug delivery and imaging-guided therapy of cancer. Biomaterials 2015, 60, 62-71.

Yong, Y.; Cheng, X.; Bao, T.; Zu, M.; Yan, L.; Yin, W.; Ge, C.; Wang, D.; Gu, Z.; Zhao, Y. Tungsten Sulfide Quantum Dots as Multifunctional Nanotheranostics for In Vivo Dual-Modal Image-Guided Photothermal/Radiotherapy Synergistic Therapy. ACS Nano 2015, 9, 12451-63.

Yang, G.; Zhang, R.; Liang, C.; Zhao, H.; Yi, X.; Shen, S.; Yang, K.; Cheng, L.; Liu, Z. Manganese Dioxide Coated WS2 @Fe3 O4 /sSiO2 Nanocomposites for pH-Responsive MR Imaging and Oxygen-Elevated Synergetic Therapy. Small 2018, 14.

Zhang, C.; Yong, Y.; Song, L.; Dong, X.; Zhang, X.; Liu, X.; Gu, Z.; Zhao, Y.; Hu, Z. Multifunctional WS2 @Polyethylene imine. Nanoplatforms for Imaging Guided Gene-Photothermal Synergistic Therapy of Cancer. Adv Healthc Mater 2016, 5, 2776-2787.

Wang, Y.; Song, S.; Lu, T.; Cheng, Y.; Song, Y.; Wang, S.; Tan, F.; Li, J.; Li, N. Oxygen-supplementing mesoporous polydopamine nanosponges with WS2 QDs-embedded for CT/MSOT/MR imaging and thermoradiotherapy of hypoxic cancer. Biomaterials 2019, 220, 119405.

Liu, Q.; Sun, C.; He, Q.; Khalil, A.; Xiang, T.; Liu, D.; Zhou, Y.; Wang, J.; Song, L. Stable metallic 1T-WS2 ultrathin nanosheets as a promising agent for near-infrared photothermal ablation cancer therapy. Nano Research 2015, 8, 3982-3991.

Horinouchi, H.; Yamamoto, H.; Komatsu, T.; Huang, Y.; Tsuchida, E.; Kobayashi, K. Enhanced radiation response of a solid tumor with the artificial oxygen carrier 'albumin-heme'. Cancer Sci 2008, 99, 1274-8.

Qiu, Y.; Lin, W.; Wang, L.; Liu, R.; Xie, J.; Chen, X.; Yang, F.; Huang, G.; Yang, H. Iron phosphide nanoparticles as a pH-responsive T1 contrast agent for magnetic resonance tumor imaging. RSC Advances 2019, 9, 30581-30584.

Liu, Y.; Zhen, W.; Wang, Y.; Liu, J.; Jin, L.; Zhang, T.; Zhang, S.; Zhao, Y.; Song, S.; Li, C.; Zhu, J.; Yang, Y.; Zhang, H. One-Dimensional Fe2 P Acts as a Fenton Agent in Response to NIR II Light and Ultrasound for Deep Tumor Synergetic Theranostics. Angew Chem Int Ed Engl 2019, 58, 2407-2412.

Tian, J.; Zhu, H.; Chen, J.; Zheng, X.; Duan, H.; Pu, K.; Chen, P. Cobalt Phosphide Double-Shelled Nanocages: Broadband Light-Harvesting Nanostructures for Efficient Photothermal Therapy and Self-Powered Photoelectrochemical Biosensing. Small 2017, 13.

Kapri, S.; Bhattacharyya, S. Cobalt Phosphide Nanorods with Controlled Aspect Ratios as Synergistic Photothermo-Chemotherapeutic Agents. ACS Applied Nano Materials 2018, 1, 5237-5245.

Liu, Y.; Zhen, W.; Wang, Y.; Liu, J.; Jin, L.; Zhang, T.; Zhang, S.; Zhao, Y.; Yin, N.; Niu, R.; Song, S.; Zhang, L.; Zhang, H. Double Switch Biodegradable Porous Hollow Trinickel Monophosphide Nanospheres for Multimodal Imaging Guided Photothermal Therapy. Nano Lett 2019, 19, 5093-5101.

Liu, Y.; Wu, J.; Jin, Y.; Zhen, W.; Wang, Y.; Liu, J.; Jin, L.; Zhang, S.; Zhao, Y.; Song, S.; Yang, Y.; Zhang, H. CopperI. Phosphide Nanocrystals for In Situ Self‐Generation Magnetic Resonance Imaging‐Guided Photothermal‐Enhanced Chemodynamic Synergetic Therapy Resisting Deep‐Seated Tumor. Adv.Funct. Mater. 2019, 29.

Sun, M.; Yang, D.; Wang, C.; Bi, H.; Zhou, Y.; Wang, X.; Xu, J.; He, F.; Gai, S.; Yang, P. AgBiS2-TPP nanocomposite for mitochondrial targeting photodynamic therapy, photothermal therapy and bio-imaging under 808 nm NIR laser irradiation. Biomater Sci 2019, 7, 4769-4781.

Qin, M. Y.; Yang, X. Q.; Wang, K.; Zhang, X. S.; Song, J. T.; Yao, M. H.; Yan, D. M.; Liu, B.; Zhao, Y. D. In vivo cancer targeting and fluorescence-CT dual-mode imaging with nanoprobes based on silver sulfide quantum dots and iodinated oil. Nanoscale 2015, 7, 19484-92.

Liu, T.; Wang, C.; Gu, X.; Gong, H.; Cheng, L.; Shi, X.; Feng, L.; Sun, B.; Liu, Z. Drug delivery with PEGylated MoS2 nano-sheets for combined photothermal and chemotherapy of cancer. Adv Mater 2014, 26, 3433-40.

Chen, J.; Zhao, X.; Tan, S. J.; Xu, H.; Wu, B.; Liu, B.; Fu, D.; Fu, W.; Geng, D.; Liu, Y.; Liu, W.; Tang, W.; Li, L.; Zhou, W.; Sum, T. C.; Loh, K. P. Chemical Vapor Deposition of Large-Size Monolayer MoSe2 Crystals on Molten Glass. J Am Chem Soc 2017, 139, 1073-1076.

Wu, S.; Liu, X.; Ren, J.; Qu, X. Glutathione Depletion in a Benign Manner by MoS2 -Based Nanoflowers for Enhanced Hypoxia-Irrelevant Free-Radical-Based Cancer Therapy. Small 2019, 15, e1904870.

Tan, L.; Wang, S.; Xu, K.; Liu, T.; Liang, P.; Niu, M.; Fu, C.; Shao, H.; Yu, J.; Ma, T.; Ren, X.; Li, H.; Dou, J.; Ren, J.; Meng, X. Layered MoS2 Hollow Spheres for Highly-Efficient Photothermal Therapy of Rabbit Liver Orthotopic Transplantation Tumors. Small 2016, 12, 2046-55.

Novoselov, K. S.; Geim, A. K.; Morozov, S. V.; Jiang, D.; Zhang, Y.; Dubonos, S. V.; Grigorieva, I. V.; Firsov, A. A. Electric field effect in atomically thin carbon films. Science 2004, 306, 666-9.

Xing, T.; Mateti, S.; Li, L. H.; Ma, F.; Du, A.; Gogotsi, Y.; Chen, Y. Gas Protection of Two-Dimensional Nanomaterials from High-Energy Impacts. Sci Rep 2016, 6, 35532.

Coleman, J. N.; Lotya, M.; O'Neill, A.; Bergin, S. D.; King, P. J.; Khan, U.; Young, K.; Gaucher, A.; De, S.; Smith, R. J.; Shvets, I. V.; Arora, S. K.; Stanton, G.; Kim, H. Y.; Lee, K.; Kim, G. T.; Duesberg, G. S.; Hallam, T.; Boland, J. J.; Wang, J. J.; Donegan, J. F.; Grunlan, J. C.; Moriarty, G.; Shmeliov, A.; Nicholls, R. J.; Perkins, J. M.; Grieveson, E. M.; Theuwissen, K.; McComb, D. W.; Nellist, P. D.; Nicolosi, V. Two-dimensional nanosheets produced by liquid exfoliation of layered materials. Science 2011, 331, 568-71.

Yin, W.; Yan, L.; Yu, J.; Tian, G.; Zhou, L.; Zheng, X.; Zhang, X.; Yong, Y.; Li, J.; Gu, Z.; Zhao, Y. High-throughput synthesis of single-layer MoS2 nanosheets as a near-infrared photothermal-triggered drug delivery for effective cancer therapy. ACS Nano 2014, 8, 6922-33.

Lee, Y. H.; Zhang, X. Q.; Zhang, W.; Chang, M. T.; Lin, C. T.; Chang, K. D.; Yu, Y. C.; Wang, J. T.; Chang, C. S.; Li, L. J.; Lin, T. W. Synthesis of large-area MoS2 atomic layers with chemical vapor deposition. Adv Mater 2012, 24, 2320-5.

Cai, Z.; Shen, T.; Zhu, Q.; Feng, S.; Yu, Q.; Liu, J.; Tang, L.; Zhao, Y.; Wang, J.; Liu, B.; Cheng, H. M. Dual-Additive Assisted Chemical Vapor Deposition for the Growth of Mn-Doped 2D MoS2 with Tunable Electronic Properties. Small 2020, 16, e1903181.

Qian, X.; Shen, S.; Liu, T.; Cheng, L.; Liu, Z. Two-dimensional TiS2. nanosheets for in vivo photoacoustic imaging and photothermal cancer therapy. Nanoscale 2015, 7, 6380-7.

Wang, S.; Li, K.; Chen, Y.; Chen, H.; Ma, M.; Feng, J.; Zhao, Q.; Shi, J. Biocompatible PEGylated MoS2 nanosheets: controllable bottom-up synthesis and highly efficient photothermal regression of tumor. Biomaterials 2015, 39, 206-17.

Li, B.; Yuan, F.; He, G.; Han, X.; Wang, X.; Qin, J.; Guo, Z. X.; Lu, X.; Wang, Q.; Parkin, I. P.; Wu, C. Ultrasmall CuCo2S4Nanocrystals: All-in-One Theragnosis Nanoplatform with Magnetic Resonance/Near-Infrared Imaging for Efficiently Photothermal Therapy of Tumors. Advanced Functional Materials 2017, 27.

Sheng, J.; Wang, L.; Han, Y.; Chen, W.; Liu, H.; Zhang, M.; Deng, L.; Liu, Y. N. Dual Roles of Protein as a Template and a Sulfur Provider: A General Approach to Metal Sulfides for Efficient Photothermal Therapy of Cancer. Small 2018, 14.

Wang, S.; Zhao, J.; Yang, H.; Wu, C.; Hu, F.; Chang, H.; Li, G.; Ma, D.; Zou, D.; Huang, M. Bottom-up synthesis of WS2 nanosheets with synchronous surface modification for imaging guided tumor regression. Acta Biomater 2017, 58, 442-454.

Ding, B.; Zheng, P.; Ma, P.; Lin, J. Manganese Oxide Nanomaterials: Synthesis, Properties, and Theranostic Applications. Adv Mater 2020, 32, e1905823.

Hong, G.; Robinson, J. T.; Zhang, Y.; Diao, S.; Antaris, A. L.; Wang, Q.; Dai, H. In vivo fluorescence imaging with Ag2S quantum dots in the second near-infrared region. Angew Chem Int Ed Engl 2012, 51, 9818-21.

Wang, S.; Li, X.; Chen, Y.; Cai, X.; Yao, H.; Gao, W.; Zheng, Y.; An, X.; Shi, J.; Chen, H. A Facile One-Pot Synthesis of a Two-Dimensional MoS2 /Bi2S3 Composite Theranostic Nanosystem for Multi-Modality Tumor Imaging and Therapy. Adv Mater 2015, 27, 2775-82.

Li, Z.; Li, Z.; Chen, L.; Hu, Y.; Hu, S.; Miao, Z.; Sun, Y.; Besenbacher, F.; Yu, M. Polyethylene glycol-modified cobalt sulfide nanosheets for high-performance photothermal conversion and photoacoustic/magnetic resonance imaging. Nano Research 2018, 11, 2436-2449.

Guan, G.; Wang, X.; Huang, X.; Zhang, W.; Cui, Z.; Zhang, Y.; Lu, X.; Zou, R.; Hu, J. Porous cobalt sulfide hollow nanospheres with tunable optical property for magnetic resonance imaging-guided photothermal therapy. Nanoscale 2018, 10, 14190-14200.

Yi, X.; Yang, K.; Liang, C.; Zhong, X.; Ning, P.; Song, G.; Wang, D.; Ge, C.; Chen, C.; Chai, Z.; Liu, Z. Imaging-Guided Combined Photothermal and Radiotherapy to Treat Subcutaneous and Metastatic Tumors Using Iodine-131-Doped Copper Sulfide Nanoparticles. Advanced Functional Materials 2015, 25, 4689-4699.

Yi, X.; Chen, L.; Chen, J.; Maiti, D.; Chai, Z.; Liu, Z.; Yang, K. Biomimetic Copper Sulfide for Chemo-Radiotherapy: Enhanced Uptake and Reduced Efflux of Nanoparticles for Tumor Cells under Ionizing Radiation. Advanced Functional Materials 2018, 28.

Li, Y.; Sun, Y.; Cao, T.; Su, Q.; Li, Z.; Huang, M.; Ouyang, R.; Chang, H.; Zhang, S.; Miao, Y. A cation-exchange controlled core-shell MnS@Bi2S3 theranostic platform for multimodal imaging guided radiation therapy with hyperthermia boost. Nanoscale 2017, 9, 14364-14375.

Gu, D.; An, P.; He, X.; Wu, H.; Gao, Z.; Li, Y.; Chen, F.; Cheng, K.; Zhang, Y.; You, C.; Sun, B. A novel versatile yolk-shell nanosystem based on NIR-elevated drug release and GSH depletion-enhanced Fenton-like reaction for synergistic cancer therapy. Colloids Surf B Biointerfaces 2020, 189, 110810.

Li, M.; Zhao, Q.; Yi, X.; Zhong, X.; Song, G.; Chai, Z.; Liu, Z.; Yang, K. Au@MnS@ZnS Core/Shell/Shell Nanoparticles for Magnetic Resonance Imaging and Enhanced Cancer Radiation Therapy. ACS Appl Mater Interfaces 2016, 8, 9557-64.

Guan, G.; Wang, X.; Li, B.; Zhang, W.; Cui, Z.; Lu, X.; Zou, R.; Hu, J. "Transformed" Fe3S4 tetragonal nanosheets: a high-efficiency and body-clearable agent for magnetic resonance imaging guided photothermal and chemodynamic synergistic therapy. Nanoscale 2018, 10, 17902-17911.

Zhang, M. K.; Wang, X. G.; Zhu, J. Y.; Liu, M. D.; Li, C. X.; Feng, J.; Zhang, X. Z. Double-Targeting Explosible Nanofirework for Tumor Ignition to Guide Tumor-Depth Photothermal Therapy. Small 2018, 14, e1800292.

Pan, X.; Li, P.; Bai, L.; Ma, J.; Li, S.; Zhang, F.; Liu, S.; Wu, Q.; Shen, H.; Liu, H. Biodegradable Nanocomposite with Dual Cell-Tissue Penetration for Deep Tumor Chemo-Phototherapy. Small 2020, 16, e2000809.

Yong, Y.; Zhou, L.; Gu, Z.; Yan, L.; Tian, G.; Zheng, X.; Liu, X.; Zhang, X.; Shi, J.; Cong, W.; Yin, W.; Zhao, Y. WS2 nanosheet as a new photosensitizer carrier for combined photodynamic and photothermal therapy of cancer cells. Nanoscale 2014, 6, 10394-403.

Jin, Q.; Liu, J.; Zhu, W.; Dong, Z.; Liu, Z.; Cheng, L. Albumin-Assisted Synthesis of Ultrasmall FeS2 Nanodots for Imaging-Guided Photothermal Enhanced Photodynamic Therapy. ACS Appl Mater Interfaces 2018, 10, 332-340.

Yang, W.; Guo, W.; Le, W.; Lv, G.; Zhang, F.; Shi, L.; Wang, X.; Wang, J.; Wang, S.; Chang, J.; Zhang, B. Albumin-Bioinspired Gd:CuS Nanotheranostic Agent for In Vivo Photoacoustic/Magnetic Resonance Imaging-Guided Tumor-Targeted Photothermal Therapy. ACS Nano 2016, 10, 10245-10257.

Zhang, L.; Chen, Q.; Zou, X.; Chen, J.; Hu, L.; Dong, Z.; Zhou, J.; Chen, Y.; Liu, Z.; Cheng, L. Intelligent protein-coated bismuth sulfide and manganese oxide nanocomposites obtained by biomineralization for multimodal imaging-guided enhanced tumor therapy. J Mater Chem B 2019, 7, 5170-5181.

He, T.; Qin, X.; Jiang, C.; Jiang, D.; Lei, S.; Lin, J.; Zhu, W. G.; Qu, J.; Huang, P. Tumor pH-responsive metastable-phase manganese sulfide nanotheranostics for traceable hydrogen sulfide gas therapy primed chemodynamic therapy. Theranostics 2020, 10, 2453-2462.

Chang, M.; Hou, Z.; Wang, M.; Wang, M.; Dang, P.; Liu, J.; Shu, M.; Ding, B.; Al Kheraif, A. A.; Li, C.; Lin, J. Cu2 MoS4 /Au Heterostructures with Enhanced Catalase-Like Activity and Photoconversion Efficiency for Primary/Metastatic Tumors Eradication by Phototherapy-Induced Immunotherapy. Small 2020, 16, e1907146.

Zhou, M.; Zhang, R.; Huang, M.; Lu, W.; Song, S.; Melancon, M. P.; Tian, M.; Liang, D.; Li, C. A chelator-free multifunctional [64Cu]CuS nanoparticle platform for simultaneous micro-PET/CT imaging and photothermal ablation therapy. J Am Chem Soc 2010, 132, 15351-8.

Chen, Y.; Cheng, L.; Dong, Z.; Chao, Y.; Lei, H.; Zhao, H.; Wang, J.; Liu, Z. Degradable Vanadium Disulfide Nanostructures with Unique Optical and Magnetic Functions for Cancer Theranostics. Angew Chem Int Ed Engl 2017, 56, 12991-12996.

Liu, Y.; Ji, X.; Liu, J.; Tong, W. W. L.; Askhatova, D.; Shi, J. Tantalum Sulfide Nanosheets as a Theranostic Nanoplatform for Computed Tomography Imaging-Guided Combinatorial Chemo-Photothermal Therapy. Adv Funct Mater 2017, 27.

Li, B.; Ye, K.; Zhang, Y.; Qin, J.; Zou, R.; Xu, K.; Huang, X.; Xiao, Z.; Zhang, W.; Lu, X.; Hu, J. Photothermal theragnosis synergistic therapy based on bimetal sulphide nanocrystals rather than nanocomposites. Adv Mater 2015, 27, 1339-45.

Li, C.; Zhang, Y.; Wang, M.; Zhang, Y.; Chen, G.; Li, L.; Wu, D.; Wang, Q. In vivo real-time visualization of tissue blood flow and angiogenesis using Ag2S quantum dots in the NIR-II window. Biomaterials 2014, 35, 393-400.

Song, C.; Zhang, Y.; Li, C.; Chen, G.; Kang, X.; Wang, Q. Enhanced Nanodrug Delivery to Solid Tumors Based on a Tumor Vasculature-Targeted Strategy. Advanced Functional Materials 2016, 26, 4192-4200.

Lee, B. H.; Suresh, S.; Ekpenyong, A. Fluorescence intensity modulation of CdSe/ZnS quantum dots assesses reactive oxygen species during chemotherapy and radiotherapy for cancer cells. J Biophotonics 2019, 12, e201800172.

Ding, L.; He, S.; Chen, D.; Huang, M.; Xu, J.; Hickey, S. G.; Eychmüller, A.; Yu, S.-H.; Miao, S. Encapsulated Cd3P2 quantum dots emitting from the visible to the near infrared for bio-labelling applications. CrystEngComm 2014, 16, 9622-9630.

Zhou, J.; Liu, Y.; Zhang, G.; Jia, Q.; Li, L. DNA-templated porous nanoplatform towards programmed "double-hit" cancer therapy via hyperthermia and immunogenicity activation. Biomaterials 2019, 219, 119395.

Liu, J.; Jin, L.; Wang, Y.; Ding, X.; Zhang, S.; Song, S.; Wang, D.; Zhang, H. A New Co-P Nanocomposite with Ultrahigh Relaxivity for In Vivo Magnetic Resonance Imaging-Guided Tumor Eradication by Chemo/Photothermal Synergistic Therapy. Small 2018, 14.

Tang, Z.; Zhang, H.; Liu, Y.; Ni, D.; Zhang, H.; Zhang, J.; Yao, Z.; He, M.; Shi, J.; Bu, W. Antiferromagnetic Pyrite as the Tumor Microenvironment-Mediated Nanoplatform for Self-Enhanced Tumor Imaging and Therapy. Adv Mater 2017, 29.

Yang, K.; Yang, G.; Chen, L.; Cheng, L.; Wang, L.; Ge, C.; Liu, Z. FeS nanoplates as a multifunctional nano-theranostic for magnetic resonance imaging guided photothermal therapy. Biomaterials 2015, 38, 1-9.

Wang, Z.; Huang, P.; Jacobson, O.; Wang, Z.; Liu, Y.; Lin, L.; Lin, J.; Lu, N.; Zhang, H.; Tian, R.; Niu, G.; Liu, G.; Chen, X. Biomineralization-Inspired Synthesis of Copper Sulfide-Ferritin Nanocages as Cancer Theranostics. ACS Nano 2016, 10, 3453-60.

Huang, H.; Li, K.; Liu, Q.; Zhao, Y.; Xu, H.; Wu, W.; Sun, K.; Ni, J.; Lin, J. Dual-response CuS@MnO2 nanoparticles with activatable CT/MR-enhanced in vivo imaging guided photothermal therapy. RSC Advances 2019, 9, 2718-2730.

Xiao, Q.; Zheng, X.; Bu, W.; Ge, W.; Zhang, S.; Chen, F.; Xing, H.; Ren, Q.; Fan, W.; Zhao, K.; Hua, Y.; Shi, J. A core/satellite multifunctional nanotheranostic for in vivo imaging and tumor eradication by radiation/photothermal synergistic therapy. J Am Chem Soc 2013, 135, 13041-8.

Chen, Q.; Xu, L.; Liang, C.; Wang, C.; Peng, R.; Liu, Z. Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy. Nat Commun 2016, 7, 13193.

Liang, C.; Xu, L.; Song, G.; Liu, Z. Emerging nanomedicine approaches fighting tumor metastasis: animal models, metastasis-targeted drug delivery, phototherapy, and immunotherapy. Chem Soc Rev 2016, 45, 6250-6269.

Chen, Q.; Hu, Q.; Dukhovlinova, E.; Chen, G.; Ahn, S.; Wang, C.; Ogunnaike, E. A.; Ligler, F. S.; Dotti, G.; Gu, Z. Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells. Adv. Mater. 2019, 31, e1900192.

Zhang, X.; Liu, J.; Yang, X.; He, G.; Li, B.; Qin, J.; Shearing, P. R.; Brett, D. J. L.; Hu, J.; Lu, X. CuCo2S4 nanocrystals as a nanoplatform for photothermal therapy of arterial inflammation. Nanoscale 2019, 11, 9733-9742.

Li, N.; Sun, Q.; Yu, Z.; Gao, X.; Pan, W.; Wan, X.; Tang, B. Nuclear-Targeted Photothermal Therapy Prevents Cancer Recurrence with Near-Infrared Triggered Copper Sulfide Nanoparticles. ACS Nano 2018, 12, 5197-5206.

Yang, T.; Wang, Y.; Ke, H.; Wang, Q.; Lv, X.; Wu, H.; Tang, Y.; Yang, X.; Chen, C.; Zhao, Y.; Chen, H. Protein-Nanoreactor-Assisted Synthesis of Semiconductor Nanocrystals for Efficient Cancer Theranostics. Advanced Materials 2016, 28, 5923-5930.

Yin, W.; Yu, J.; Lv, F.; Yan, L.; Zheng, L. R.; Gu, Z.; Zhao, Y. Functionalized Nano-MoS2 with Peroxidase Catalytic and Near-Infrared Photothermal Activities for Safe and Synergetic Wound Antibacterial Applications. ACS Nano 2016, 10, 11000-11011.

Li, Z.; Hu, S.; Liu, J.; Hu, Y.; Chen, L.; Jiang, T.; Sun, L.; Sun, Y.; Besenbacher, F.; Chen, C.; Yu, M. Cobalt Phosphide Nanoparticles Applied as a Theranostic Agent for Multimodal Imaging and Anticancer Photothermal Therapy. Particle & Particle Systems Characterization 2018, 35.

Chen, F.; Yang, D.; Shen, H.; Deng, M.; Zhang, Y.; Zhong, G.; Hu, Y.; Weng, L.; Luo, Z.; Wang, L. Hydrothermal synthesis of novel rhombic dodecahedral SnS nanocrystals for highly efficient photothermal therapy. Chem Commun Camb. 2019, 55, 2789-2792.

Yang, D.; Chen, F.; He, S.; Shen, H.; Hu, Y.; Feng, N.; Wang, S.; Weng, L.; Luo, Z.; Wang, L. One-pot growth of triangular SnS nanopyramids for photoacoustic imaging and photothermal ablation of tumors. New Journal of Chemistry 2019, 43, 13256-13262.

Kue, C. S.; Kamkaew, A.; Lee, H. B.; Chung, L. Y.; Kiew, L. V.; Burgess, K. Targeted PDT agent eradicates TrkC expressing tumors via photodynamic therapy PDT. . Mol Pharm 2015, 12, 212-22.

Xu, J.; Gulzar, A.; Liu, Y.; Bi, H.; Gai, S.; Liu, B.; Yang, D.; He, F.; Yang, P. Integration of IR-808 Sensitized Upconversion Nanostructure and MoS2 Nanosheet for 808 nm NIR Light Triggered Phototherapy and Bioimaging. Small 2017, 13.

Liu, B.; Li, C.; Chen, G.; Liu, B.; Deng, X.; Wei, Y.; Xia, J.; Xing, B.; Ma, P.; Lin, J. Synthesis and Optimization of MoS2@Fe3O4-ICG/PtIV. Nanoflowers for MR/IR/PA Bioimaging and Combined PTT/PDT/Chemotherapy Triggered by 808 nm Laser. Adv Sci Weinh. 2017, 4, 1600540.

Lv, K.; Lin, H.; Qu, F. Biodegradable hollow Co3S4@N-doped carbon as enhanced PTT/PDT agent for multimodal MR/thermal imaging and synergistic antitumor therapy. Chemical Engineering Journal 2020, 392.

Wang, X.; Zhong, X.; Zha, Z.; He, G.; Miao, Z.; Lei, H.; Luo, Q.; Zhang, R.; Liu, Z.; Cheng, L. Biodegradable CoS2 nanoclusters for photothermal-enhanced chemodynamic therapy. Applied Materials Today 2020, 18.

Hosseini, M.; Kahkha, M. R. R.; Fakhri, A.; Tahami, S.; Lariche, M. J. Degradation of macrolide antibiotics via sono or photo coupled with Fenton methods in the presence of ZnS quantum dots decorated SnO2 nanosheets. J Photochem Photobiol B 2018, 185, 24-31.

Wang, D.; Dong, H.; Li, M.; Cao, Y.; Yang, F.; Zhang, K.; Dai, W.; Wang, C.; Zhang, X. Erythrocyte-Cancer Hybrid Membrane Camouflaged Hollow Copper Sulfide Nanoparticles for Prolonged Circulation Life and Homotypic-Targeting Photothermal/Chemotherapy of Melanoma. ACS Nano 2018, 12, 5241-5252.

Chang, Y.; Cheng, Y.; Feng, Y.; Jian, H.; Wang, L.; Ma, X.; Li, X.; Zhang, H. Resonance Energy Transfer-Promoted Photothermal and Photodynamic Performance of Gold-Copper Sulfide Yolk-Shell Nanoparticles for Chemophototherapy of Cancer. Nano Lett 2018, 18, 886-897.

Kang, Y.; Yu, X.; Fan, X.; Aodenggerile; Zhao, S.; Tu, C.; Yan, Z.; Wang, R.; Li, W.; Qiu, H. Tetramodal Imaging and Synergistic Cancer Radio-Chemotherapy Enabled by Multiple Component-Encapsulated Zeolitic Imidazolate Frameworks. ACS Nano 2020, 14, 4336-4351.

Fu, L. H.; Wan, Y.; Qi, C.; He, J.; Li, C.; Yang, C.; Xu, H.; Lin, J.; Huang, P. Nanocatalytic Theranostics with Glutathione Depletion and Enhanced Reactive Oxygen Species Generation for Efficient Cancer Therapy. Adv Mater 2021, 33, e2006892.

Lin, G.; Revia, R. A.; Zhang, M. Inorganic Nanomaterial‐Mediated Gene Therapy in Combination with Other Antitumor Treatment Modalities. Advanced Functional Materials 2020.

Ren, T.; Li, L.; Cai, X.; Dong, H.; Liu, S.; Li, Y. Engineered polyethylenimine/graphene oxide nanocomposite for nuclear localized gene delivery. Polymer Chemistry 2012, 3.

Herweijer, H.; Wolff, J. A. Progress and prospects: naked DNA gene transfer and therapy. Gene Ther 2003, 10, 453-8.

Vile, R. G.; Russell, S. J.; Lemoine, N. R. Cancer gene therapy: hard lessons and new courses. Gene Therapy 2000, 7, 2-8.

Tal, J. Adeno-associated virus-based vectors in gene therapy. J Biomed Sci 2000, 7, 279-91.

Sun, Y.; Zhang, J.; Yin, H.; Yin, J. MicroRNA-mediated suppression of P-glycoprotein by quantum dots in lung cancer cells. J Appl Toxicol 2020, 40, 525-534.

Anas, A.; Akita, H.; Harashima, H.; Itoh, T.; Ishikawa, M.; Biju, V. Photosensitized breakage and damage of DNA by CdSe-ZnS quantum dots. J Phys Chem B 2008, 112, 10005-11.

Lin, G.; Chen, T.; Zou, J.; Wang, Y.; Wang, X.; Li, J.; Huang, Q.; Fu, Z.; Zhao, Y.; Lin, M. C.; Xu, G.; Yong, K. T. Quantum Dots-siRNA Nanoplexes for Gene Silencing in Central Nervous System Tumor Cells. Front Pharmacol 2017, 8, 182.

Tian, Q.; Hu, J.; Zhu, Y.; Zou, R.; Chen, Z.; Yang, S.; Li, R.; Su, Q.; Han, Y.; Liu, X. Sub-10 nm Fe3O4@Cu2-x. S core-shell nanoparticles for dual-modal imaging and photothermal therapy. J Am Chem Soc 2013, 135, 8571-7.

Liu, J.; Wang, P.; Zhang, X.; Wang, L.; Wang, D.; Gu, Z.; Tang, J.; Guo, M.; Cao, M.; Zhou, H.; Liu, Y.; Chen, C. Rapid Degradation and High Renal Clearance of Cu3BiS3 Nanodots for Efficient Cancer Diagnosis and Photothermal Therapy in Vivo. ACS Nano 2016, 10, 4587-98.




How to Cite

Zhao, X. ., An, Q. ., & Cai, J. . (2023). Recent Progress in the Transition Metal Sulfide/Phosphide for Cancer Theranostic Applications. Cancer Insight, 1(2), 52–75.